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Specifically, rodent studies showed an increased incidence of thyroid C-cell tumours (medullary thyroid carcinoma) when exposed to GLP-1 receptor agonists at doses significantly higher than those used therapeutically in humans

However, eligibility is also extended to individuals with a lower BMI of 27 or greater if they have at least one weight-related health condition

Clin Res Hepatol Gastroenterol 46(6):101922 Niu S, Chen S, Chen X, Ren Q, Yue L, Pan X, Zhao H, Li Z, Chen X (2022) Semaglutide ameliorates metabolism and hepatic outcomes in an NAFLD mouse model

Rotating injection sites with each weekly dose helps minimize these reactions

Remove the patch, fold in half, and discard