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In SURMOUNT-3, 600 participants are randomized to receive either tirzepatide at the maximally tolerated dose or placebo following a structured intensive 12-week lifestyle intervention

While there's currently no cure for most cases of dementia, research focuses on treating conditions that cause abnormal changes within the brain

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Several Phase 3 trials cover type 2 diabetes (TRANSCEND-T2D), obstructive sleep apnea, MASLD, chronic kidney disease in patients with type 2 diabetes, knee osteoarthritis (TRIUMPH-4), and cardiovascular outcomes

Shao CY, Mirra SS, Sait HB, Sacktor TC, Sigurdsson EM