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Several research reviews suggest that berberine may have modest benefits for weight-related measures, like this one and this one, which found reductions in body mass index (BMI) and waist circumference

For skin and connective tissue support, some researchers layer in GHK-Cu for wound healing

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Body weight change from baseline to 13 weeks was 14.7% with 15 mg VK2735, 12.9% with 10 mg VK2735, 10.9% with the 5 mg dose and 9.1% with the 2.5 mg dose vs