These early studies confirmed the once-weekly dosing feasibility and identified the gastrointestinal side effectsprimarily nausea, vomiting, and diarrheathat would become characteristic of GLP-1 receptor agonist therapy
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Phase 3 clinical trials testing GLP-1 RAs for weight management have demonstrated mean weight reduction of 8% to 15%, with 63% to 86% of patients achieving a 5% or greater reduction in body weight, and 33% to 69% achieving a 10% or greater reduction after 13 to 17 months of use
Results Cell differentiation Changes in morphology of Chub-S7 cells and lipid droplet accumulation were observed using light microscopy