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It is a substance occurring naturally in humans, where it is synthesized endogenously in the liver, kidneys, and brain

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euphoria , sedation , muscle relaxation, hypotension , bradycardia , & decreased perception of pain It may also affect 1 adrenergic, histamine, serotonin, and opioid receptors (Hoffman et al, 2001

Results: A total of 1014 patients were included: 626 (62%) did not develop AF at any point, 202 had kAF (20%), and 186 (18%) had AFDAS

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