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The global NAFLD epidemic

Obese and lean mice were given either saline, AOD9604, or hGH through an osmotic pump over the course of 14 days

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Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome

FOXO4-DRI, designed to disrupt the FOXO4-p53 interaction, was tested on senescent TM3 Leydig cells