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To further evaluate the levels of joint inflammation and cartilage damage, histological analysis of rat ankle joint sections was performed

Specifically, the UL of 1,000 mg/day of -tocopherol in any supplemental form (equivalent to 1,500 IU/day of RRR --tocopherol or 1,100 IU/day of all - rac --tocopherol) corresponds to the highest dose unlikely to result in hemorrhage in almost all adults (2)

Generally well tolerated, but dosing should be vet-guided especially with medications or chronic disease

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Some patients experience an immediate sense of alertness, while others notice gradual improvements over several days