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Last reviewed: June 15, 2026 Last updated: June 15, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

However, given the widespread expression of PDE4 enzymes in diverse tissues, such combinatorial approaches will require rigorous safety and specificity profiling

The GI side effect rates are roughly comparable at effective doses

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Sleep apnea The issue An estimated 30 million people in the United States suffer from obstructive sleep apnea, in which breathing repeatedly stops and starts during sleep